The field of microbial genomics is rapidly advancing, yet there is a notable opportunity to bridge the gap in undergraduate education linking microbial physiology and genomics, particularly for underrepresented minorities. We aim to integrate advanced microbiology and genomics into its curriculum, enhancing hands-on learning opportunities. This initiative has updated two courses: biotechnology explorations and genomics and bioinformatics, linked through an extended-Course-based Research Experience (eCURE). Students kick off with engaging activities like pipetting by design, mastering this fundamental skill through interactive methods. As they progress, they dive into microbial enrichments, culturing unknown microbes from seawater, high-throughput microbial physiology experiments, data analysis, and genome sequencing, fostering a sense of scientific contribution and ownership. Biomathematical skills are seamlessly woven throughout the curriculum. This project aims to bolster technical skills, scientific communication, and pathways to STEM careers, serving as a model for other HBCUs to elevate diversity and inclusion in STEM, particularly in microbiology.