This session will outline how the Host-Pathogen Interactions course-based research experience at the University of Maryland successfully engages first-year students in microbiology research utilizing single-gene knockout strains of E. coli to determine if disruption of specific host cell metabolic pathways impacts viral replication. Students in this CURE gain introductory training in microbiology laboratory techniques, formulate testable hypotheses, write research proposals, and produce and present summative research posters. Attendees will leave this session with an understanding of how to run an engaging microbiology-focused CURE suitable for first-year students.