Immunology education often faces challenges in engaging students and fostering a deep understanding of complex concepts. Traditional methods may not always resonate with students or effectively convey the intricate workings of the immune system. To address these challenges, a novel teaching and assessment method using student-created posters with analogies has been developed. Can student-created posters with analogies effectively deepen students' understanding of immunological concepts, foster creativity, enhance communication skills, and serve as a meaningful summative assessment tool? Students in a microbiology course are tasked with creating posters that explain immune system processes using analogies. Rubrics are used to assess the clarity, creativity, and relevance of analogies. Qualitative analysis of posters shows a range of creative and effective analogies, demonstrating enhanced communication skills. Students successfully incorporate personal interests and experiences into their analogies, promoting engagement and ownership of learning. The posters deepen understanding, foster creativity, enhance communication skills, and serve as a meaningful summative assessment tool. This approach engages students in active learning, encourages critical thinking, and promotes a deeper appreciation of the immune system's complexities. In conclusion, integrating student-created posters with analogies into immunology education offers a dynamic and effective way to engage students, promote active learning, and assess comprehension and communication skills. This innovative approach can enhance the overall learning experience and contribute to a deeper understanding of this biological system.